发明名称 |
S-ENANTIOMER OF TETRACYCLIC INDOLE DERIVATIVE AS PBR LIGANDS |
摘要 |
The present invention concerns in vivo imaging and in particular in vivo imaging of translocator protein (TSPO, formerly known as the peripheral benzodiazepine receptor). An indole-based in vivo imaging agent is provided that overcomes problems relating to known TSPO-binding radiotracers. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said precursor compound. Other aspects of the invention include a method for the synthesis of the in vivo imaging agent of the invention comprising use of the precursor compound of the invention, a kit for carrying out said method, and a cassette for carrying out an automated version of said method. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent. |
申请公布号 |
EP3046591(A1) |
申请公布日期 |
2016.07.27 |
申请号 |
EP20140771301 |
申请日期 |
2014.09.19 |
申请人 |
GE HEALTHCARE LIMITED |
发明人 |
TRIGG, WILLIAM, JOHN;JONES, PAUL, ALEXANDER |
分类号 |
A61K51/04;A61K31/404;A61K31/407;A61P25/00;A61P35/00;C07D495/04 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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