| 摘要 |
The problem addressed by the present invention is to provide a novel separating medium for hydrophilic interaction chromatography useful in separating hydrophilic compounds. The hydrophilic interaction chromatography separating medium, which is formed from a support and a ligand carried by the support, is a separating medium wherein the ligand is a (meth)acrylic polymer having a constituent unit derived from the compound indicated by formula (I). (In formula (I): there are one or two double bonds between atoms configuring a heterocycle; X 1 is selected from the group consisting of S, SCH 3 + , O, NH, NCH 3 , CH 2 , CHR, and CR 1 R 2 ; and X 2 , X 3 , and X 4 are each selected from the group consisting of N, NH, NCH 3 , CH 2 , CHR, NCH 3 + , CH, CR, and CR 1 R 2 . ; R 1 and R 2 are each a substituted or unsubstituted alkyl having 1-18 carbon atoms, an aryl having 6-18 carbon atoms, an alkenyl having 2-18 carbon atoms, an alkynyl having 2-18 carbon atoms, an aralkyl having 7-18 carbon atoms, an acyl having 2-18 carbon atoms, a cycloalkyl having 3-18 carbon atoms, a carboxyl, an amino, an aryloxy having 6-18 carbon atoms, an alkoxy having 1-18 carbon atoms, a halo, a hydroxy, a nitro, or a cyano. R is a substituted or unsubstituted alkyl having 1-18 carbon atoms, an aryl having 6-18 carbon atoms, an alkenyl having 2-18 carbon atoms, an alkynyl having 2-18 carbon atoms, an aralkyl having 7-18 carbon atoms, an acyl having 2-18 carbon atoms, a cycloalkyl having 3-18 carbon atoms, a carboxyl, an amino, an aryloxy having 6-18 carbon atoms, an alkoxy having 1-18 carbon atoms, a halo, a hydroxy, a nitro, or a cyano. ; At least two of X 1 , X 2 , X 3 , and X 4 are not CH 2 , CH, CR, or CR 1 R 2 , and R 3 is H or CH 3 .) |
