发明名称 |
USE OF GLYCEROPHOSPHOLIPIDS FOR JOINT LUBRICATION |
摘要 |
The present invention concerns methods of joint lubrication and/or prevention of cartilage wear making use of liposomes having membranes with at least one phospholipid (PL) of the group consisting of a glycerophospholipid (GPL) having two, being the same or different, C12-C16 hydrocarbon chain and a sphingolipid (SPL) having a C12-C18 hydrocarbon chain, the one or more membranes having a phase transition temperature in which solid ordered (SO) to liquid disordered (LD) phase transition occurs, the phase transition temperature being within a temperature of about 20° C. to about 39° C. for lubrication of joints. |
申请公布号 |
EP2079442(B1) |
申请公布日期 |
2016.07.27 |
申请号 |
EP20070827189 |
申请日期 |
2007.10.07 |
申请人 |
HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED;TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.;YISSUM RESEARCH DEVELOPMENT COMPANY, OF THE HEBREW UNIVERSITY OF JERUSALEM |
发明人 |
BARENHOLZ, YECHEZKEL;NITZAN, DORRIT;ETSION, IZHAK;SCHROEDER, AVI;HALPERIN, GRIGORY;SIVAN, SARIT |
分类号 |
A61L27/50;A61K9/00;A61K9/127;A61K31/685 |
主分类号 |
A61L27/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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