DERIVATIVES OF CIS-TETRAHYDRO-SPIRO(CYCLOHEXANE-1,1'-PYRIDO[3,4-b]INDOLE)-4-AMINE EFFECTIVE IN TREATING NEUROPATHIC AND/OR CHRONIC PAIN

摘要

FIELD: chemistry.SUBSTANCE: invention relates to derivatives of cis-tetrahydro-spiro(cyclohexane-1,1'-pyrido[3,4-b]indole)-4-amine of formula (III) in form of free bases or physiologically acceptable salts, where Rdenotes H or CH; R, R, Rand Rdenotes H or halogen. Invention also relates to a pharmaceutical composition based on compound of formula (III), having activity on ORL1 receptor and µ-opioid receptor.EFFECT: obtaining novel compounds having useful biological properties.8 cl, 7 tbl, 22 ex