The invention relates to immunogenic compositions comprising recombinant multimeric influenza proteins or parts thereof fused to a streptavidin affinity tag, preferably recombinant trimeric influenza virus hemagglutinin and/or recombinant tetrameric influenza virus neuraminidase, or vectors comprising nucleic acid sequences encoding such influenza proteins. The inventions further relate to methods for the preparation of such immunogenic compositions and uses thereof and methods for eliciting an immune response in an individual.
申请公布号
EP2555795(B1)
申请公布日期
2016.07.13
申请号
EP20110715069
申请日期
2011.04.08
申请人
UNIVERSITEIT UTRECHT HOLDING B.V.
发明人
ROTTIER, PETRUS, JOSEPHUS, MARIE;BOSCH, BEREND, JAN;DE HAAN, CORNELIS, ALEXANDER, MARIA