| 发明名称 |
HUMANIZED ANTI-HMGB1 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF |
| 摘要 |
The present invention provides a humanized anti-HMGB1 antibody which specifically binds to a sequence consisting of the C-terminal 8 amino acid residues (EEEDDDDE) of HMGB1 protein and is effective for treatment or prevention of various inflammatory diseases related to this protein, as well as an antigen-binding fragment thereof. The present invention also provides a pharmaceutical composition comprising such an antibody or antigen-binding fragment thereof. |
| 申请公布号 |
EP2949675(A4) |
申请公布日期 |
2016.07.13 |
| 申请号 |
EP20130872417 |
申请日期 |
2013.12.06 |
| 申请人 |
EVEC INCORPORATED;NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY |
发明人 |
TAKADA KENZO;TORASHIMA TAKASHI;NISHIBORI MASAHIRO |
| 分类号 |
C07K16/46;A61K39/00;A61K39/395;A61P1/16;A61P9/10;A61P11/00;A61P13/12;A61P25/04;A61P25/28;A61P29/00;C07K16/18;C07K16/24;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09 |
主分类号 |
C07K16/46 |
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