发明名称 |
METHOD FOR PRODUCING A SPIROOXINDOLE DERIVATIVE |
摘要 |
The present invention is intended to provide a method for efficiently producing and providing a compound having a spirooxindole skeleton, for example, a compound having a spirooxindole skeleton and having antitumor activity that inhibits the interaction between Mdm2 protein and p53 protein, or an intermediate thereof, using an asymmetric catalyst. A compound having an optically active tricyclic dispiroindole skeleton is efficiently obtained through a catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid. |
申请公布号 |
EP3042906(A1) |
申请公布日期 |
2016.07.13 |
申请号 |
EP20140842419 |
申请日期 |
2014.09.03 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
YAMAUCHI, MOTOSHI;NAKAYAMA, KEIJI |
分类号 |
C07D487/10;B01J23/72;B01J27/122;B01J31/02;B01J31/04;B01J31/22;C07B53/00;C07B61/00;C07D491/20 |
主分类号 |
C07D487/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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