发明名称 |
MACROCYCLIC PEPTIDE, METHOD FOR PRODUCING SAME, AND SCREENING METHOD USING MACROCYCLIC PEPTIDE LIBRARY |
摘要 |
An object of the present invention is to provide a peptide excellent in resistance against metabolism, having a stable structure in vivo, and capable of penetrating a cell membrane and reaching in cells. The present invention provides a macrocyclic peptide having a macrocyclic structure comprised of four or more amino acids. At least two amino acids not adjacent to each other have a hydrophobic side chain and the hydrophobic side chains interact with each other inside the ring of the macrocyclic peptide in a hydrophilic environment. |
申请公布号 |
EP3040417(A1) |
申请公布日期 |
2016.07.06 |
申请号 |
EP20140839993 |
申请日期 |
2014.08.26 |
申请人 |
THE UNIVERSITY OF TOKYO |
发明人 |
SUGA, HIROAKI |
分类号 |
C12N15/09;C07K7/04;C07K7/06;C07K7/08;C12P21/00;C12Q1/68;G01N33/566 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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