发明名称 |
BISPECIFIC ANTIBODIES AND METHODS FOR PRODUCTION THEREOF |
摘要 |
The invention relates to an ex vivo method for the generation of a bispecific antibody, comprising the steps of: a) providing a first antibody having a first binding specificity, wherein said first antibody comprises an IgG4-like CH3 region, b) providing a second antibody having a second binding specificity which differs from said first binding specificity, wherein said second antibody comprises an IgG4-like CH3 region, c) incubating said first and second antibodies together under reducing conditions which allow the cysteines in the core hinge region to undergo disulfide-bond isomerization, and d) obtaining a bispecific antibody. The invention furthermore relates to bispecific antibodies obtainable by the method of the invention. |
申请公布号 |
EP2139924(B1) |
申请公布日期 |
2016.07.06 |
申请号 |
EP20080715601 |
申请日期 |
2008.03.28 |
申请人 |
GENMAB A/S |
发明人 |
SCHUURMAN, JANINE;VINK, TOM;WINKEL, JAN VAN DE;LABRIJN, ARAN, FRANK;AALBERSE, ROB;KOLFSCHOTEN, MARIJN VAN DER NEUT;PARREN, PAUL |
分类号 |
C07K16/46;C07K16/00;C07K16/28 |
主分类号 |
C07K16/46 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|