发明名称 Combination therapy associating a TGF-beta antagonist with a chemotherapeutic agent
摘要 The invention concerns a pharmaceutical composition comprising at least one stimulator of the immune cell functions and at least one substance inhibiting the cell proliferation and/or inducing cell death. In a preferred embodiment the stimulator of the function of the immune system and/or the immune cells are antagonists of TGF-beta selected from the group of oligonucleotides hybridizing with an area of the messenger RNA and/or DNA encoding TGF-beta and the at least one substance inhibiting cell proliferation and/or inducing cell death is selected from the group of temozolomide, nitrosoureas, Vinca alkaloids, antagonists of the purine and pyrimidines bases, cytoststatic active antibiotics, caphthotecine derivatives, anti estrogens, anti-androgens and analogs of gonadotropin releasing hormon.
申请公布号 EP2248895(B1) 申请公布日期 2016.07.06
申请号 EP20100009016 申请日期 2004.12.20
申请人 ISARNA THERAPEUTICS GMBH 发明人 SCHLINGENSIEPEN, KARL-HERMANN;SCHLINGENSIEPEN, REIMAR
分类号 C12N15/113;A61K31/04;A61K31/166;A61K31/52;A61K31/7048;A61K31/7125;A61K38/00;A61K38/18;A61P35/00;C07K14/495;C12N15/11 主分类号 C12N15/113
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