| 摘要 |
An aniline compound such as aniline, 2,3-difluoroaniline, or 3-fluoroaniline; and a halo-oxirane compound such as 2-chloro-2-(diethoxymethyl)-3-methyloxirane and the like are caused to react in the presence of a base such as sodium bicarbonate to obtain an N-substituted aniline compound such as 2-chloro-1,1-diethoxy-3-(phenylamino)butan-2-ol, 2-chloro-3-(2,3-difluoroamino)-1,1-diethoxybutan-2-ol, or 2-chloro-1,1-diethoxy-3-(3-fluorophenylamino)butan-2-ol; and then causing the N-substituted aniline compound to react in the presence of an acid such as hydrochloric acid to obtain a 3-hydroxyquinoline derivative such as 2-methylquinolin-3-ol, 7,8-difluoro-2-methylquinolin-3-ol, or 7-fluoro-2-methylquinolin-3-ol, 5-fluoro-2-methylquinolin-3-ol. |
