发明名称 |
CELL PENETRATING CONJUGATES AND METHODS OF USE THEREOF |
摘要 |
Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates. |
申请公布号 |
EP3038639(A1) |
申请公布日期 |
2016.07.06 |
申请号 |
EP20140839093 |
申请日期 |
2014.08.29 |
申请人 |
CITY OF HOPE |
发明人 |
LI, LIN;SHIVELY, JOHN ERNEST;SWIDERSKI, PIOTR MAREK;HERRMANN, ANDREAS;YU, HUA |
分类号 |
A61K38/14;A61K38/00;A61K39/00;A61K39/44;C07K16/08;C07K16/18;C07K16/40 |
主分类号 |
A61K38/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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