发明名称 |
PROBES COMPRISING FLUORESCENT ARTIFICIAL NUCLEOBASES AND USE THEREOF FOR DETECTION OF SINGLE BASE ALTERATION |
摘要 |
The present invention relates to forced intercalation probes (FIT-probes) comprising at least one nucleoside analogue which comprises at least a fluorescent artificial nucleobase directly bound to a carbon of a modified sugar moiety wherein said modified sugar moiety is a carba-sugar or an amino acid nucleic acid (AANA). Thereby the nucleoside analogue is incorporated into DNA or RNA in the place of a single native base. |
申请公布号 |
EP3040341(A1) |
申请公布日期 |
2016.07.06 |
申请号 |
EP20160153107 |
申请日期 |
2010.09.08 |
申请人 |
HUMBOLDT-UNIVERSITÄT ZU BERLIN |
发明人 |
SEITZ, OLIVER;BETHGE, LUCAS;HAINKE, SVEN |
分类号 |
C07H21/00;C12Q1/68 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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