发明名称 |
ENGINEERED ANTIBODY-INTERFERON MUTANT FUSION MOLECULES |
摘要 |
The field of the present invention relates to genetically engineered fusion molecules, methods of making said fusion molecules, and uses thereof in anti-tumor immunotherapies. More specifically, the present invention relates to fusion molecule constructs wherein a tumor associated antigen (TAA) antibody (Ab) serves as a targeting moiety to selectively deliver a cytokine to a tumor cell for purposes of killing or inhibiting the growth or proliferation of said tumor cell. In various embodiments, the engineered fusion molecules comprise a TAA Ab fused to an interferon-alpha (IFN-α) mutant molecule. The engineered Ab-IFN-α mutant fusion molecules of the present invention demonstrate improved therapeutic index and preserved or increased efficacy as compared to Ab-wildtype IFN-α fusion molecules, and/or demonstrate improved PK properties as compared to Ab-wildtype IFN-α fusion molecules. |
申请公布号 |
EP2822575(A4) |
申请公布日期 |
2016.07.06 |
申请号 |
EP20130758471 |
申请日期 |
2013.03.04 |
申请人 |
IMMUNGENE, INC. |
发明人 |
GREWAL, IQBAL;KHARE, SANJAY, D.;GRESSER, MICHAEL;SYED, RASHID |
分类号 |
A61K38/21;A61K39/395;A61K45/06;A61P35/00;C07K14/56;C07K16/18;C07K16/28;C07K16/30;C07K16/32 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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