发明名称 |
NASAL DRUG PRODUCTS AND METHODS OF THEIR USE |
摘要 |
Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided. |
申请公布号 |
US2016184294(A1) |
申请公布日期 |
2016.06.30 |
申请号 |
US201514950707 |
申请日期 |
2015.11.24 |
申请人 |
Lightlake Therapeutics, Inc. |
发明人 |
Crystal Roger;Weiss Michael Brenner |
分类号 |
A61K31/485;A61M15/08;A61M11/00;A61K9/00;A61K9/08 |
主分类号 |
A61K31/485 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treatment of opioid overdose or a symptom thereof,
comprising nasally administering to a patient in need thereof a dose of naloxone hydrochloride using a single-use, pre-primed device adapted for nasal delivery of a pharmaceutical composition to a patient by one actuation of said device into one nostril of said patient, having a single reservoir comprising a pharmaceutical composition which is an aqueous solution of about 100 μL comprising: about 4 mg naloxone hydrochloride or a hydrate thereof; between about 0.2 mg and about 1.2 mg of an isotonicity agent; between about 0.005 mg and about 0.015 mg of a compound which is at least one of a preservative, a cationic surfactant, and a permeation enhancer; between about 0.1 mg and about 0.5 mg of a stabilizing agent; and an amount of an acid sufficient to achieve a pH of 3.5-5.5. |
地址 |
New York NY US |