DNA Aptamer Specifically Binding to EN2 (Engrailed-2) and Use Thereof

摘要

The present invention relates to a DNA aptamer specifically binding to EN2 (Engrailed-2), a biosensor for diagnosing prostate cancer having the same, and a method of diagnosing prostate cancer. A strong binding force and excellent specificity of the DNA aptamer of the present invention and the biosensor using the same with respect to EN2 proteins were identified. A detection specificity problem of a prostate-specific antigen (PSA) test used for prostate cancer diagnosis of the related art was addressed. Therefore, the present invention is expected to be beneficially used for early diagnosis of prostate cancer more effectively and increase diagnostic accuracy.

主权项

1. A DNA aptamer specifically binding to EN2 (Engrailed-2) and having a nucleotide sequence selected from among SEQ ID NOs 5 to 10.