Efficient mucosal vaccination mediated by the neonatal Fc receptor

摘要

The present invention relates to methods and compositions for enhancing delivery of vaccine antigens to the mucosal epithelium, the composition comprising an antigen from an infectious agent fused with an Fc fragment of an immunoglobulin recognized by the neonatal receptors (FcRn). The composition is effective in eliciting a protective long-term memory T cell immune response against infection at a distant mucosal site.

主权项

1. A vaccine comprising a fusion protein comprising an Fc fragment of an immunoglobulin recognized by the neonatal receptors (FcRn) in a subject fused to a desired antigen, wherein said vaccine is administered to a mucosal epithelium and induces in said subject the formation of memory lymphocytes specific for said antigen.