Campylobacter Immunogenic Compositions and Uses Thereof

摘要

The present invention provides immunogenic compositions against Campylobacter and methods for using the immunogenic composition to generate an immune response against Campylobacter and/or reduce intestinal colonization by Campylobacter.

主权项

1. An immunogenic composition, comprising
(a) one or more polynucleotide encoding two or more proteins including
(i) a protein comprising an amino acid sequence at least 80 percent identical to SEQ ID NO:4 (Cj0588 protein), or antigenic portions thereof, and(ii) one or more proteins comprising an amino acid sequence at least 80 percent identical to a protein selected from the group consisting of SEQ ID NO:6 (Cj0248 protein), SEQ ID NO: 142 (Cj1534c protein), SEQ ID NO: 108 (Cj1656c protein), SEQ ID NO:110 (Cj0428 protein), SEQ ID NO:112 (Cj0168c protein), SEQ ID NO:114 (Cj0427 protein), SEQ ID NO:116 (Cj0113 protein), SEQ ID NO:118 (Cj0982c protein), SEQ ID NO:120 (Cj0921c protein), SEQ ID NO: 122 (Cj1259 protein), SEQ ID NO:124 (Cj1339c protein), SEQ ID NO:126 (Cj0034c protein), SEQ ID NO:128 (Cj0404 protein), SEQ ID NO:130 (Cj0365c protein), SEQ ID NO: 132 (Cj0755 protein), and SEQ ID NO: 134 (Cj0420 protein), or antigenic portions thereof; and (b) a promoter operatively linked to each of the one or more polynucleotide, wherein the promoter region is capable of directing expression of the encoded protein(s).