COMPOSITION FOR REDUCING NERVOUS SYSTEM INJURY AND METHOD OF MAKING AND USE THEREOF

摘要

This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.

主权项

1. A method for reducing nerve injury in a subject, comprising:
administering to said subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog selected from the group consisting of benzamil, methylated analogs of benzamil, phenmil, 5-(N-ethyl-N-isobutyl)-amiloride (EIPA), KB-R7943, 5-(N-methyl-N-isobutyl) amiloride, 5-(N,N-hexamethylene) amiloride and 5-(N,N-dimenthyl) amiloride hydrochloride, or a pharmaceutically acceptable salt thereof.