| 主权项 |
1. A method for the treatment of glomerulosclerosis or glomerulonephritis in a subject comprising administering to the subject an effective amount of a cyclohexenone compound having the structure: wherein each of X and Y independently is oxygen, NR5 or sulfur; R is a hydrogen or C(═O)C1-C8alkyl; each of R1, R2 and R3 independently is a hydrogen, methyl or (CH2)m—CH3; R4 is NR5R6, OR5, OC(═O)R7, C(═O)OR5, C(═O)R5, halogen, 5 or 6-membered lactone, C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, aryl, glucosyl, wherein the 5 or 6-membered lactone, C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, aryl, and glucosyl are optionally substituted with one or more substituents selected from NR5R6, OR5, OC(═O)R7, C(═O)OR5, C(═O)R5, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C8 haloalkyl, and C1-C8 alkoxy; each of R5 and R6 is independently a hydrogen or C1-C8alkyl; R7 is a C1-C8alkyl, OR5 or NR5R6; m=1-12; and n=1-12; or a pharmaceutically acceptable salt, metabolite, solvate or prodrug thereof. |
