发明名称 |
ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF |
摘要 |
Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject. |
申请公布号 |
EA023406(B1) |
申请公布日期 |
2016.06.30 |
申请号 |
EA20100070553 |
申请日期 |
2008.10.29 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
CAI YUPING, ANTHONY;GATELY DENNIS, PATRICK;HE LUHONG;LEUNG DONMIENNE, DOEN;LUAN PENG;SWANSON BARBARA, ANNE;TANG YING;WITCHER DERRICK, RYAN |
分类号 |
C07K16/18 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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