发明名称 |
Tropomyosin-related kinase (Trk) inhibitors |
摘要 |
Tropomyosin-related kinase inhibitors (Trk inhibitors) are small molecule compounds useful in the treatment of disease. Trk inhibitors can be used as pharmaceutical agents and in pharmaceutical compositions. Trk inhibitors are useful in the treatment of inflammatory diseases, autoimmune disease, defects of bone metabolism and/or cancer, and are particularly useful in the treatment of osteoarthritis (OA), pain, and pain associated with OA. Trk inhibitors are also useful for inhibiting tropomyosin-related kinase A (TrkA), tropomyosin-related kinase B (TrkB), tropomyosin-related kinase C (TrkC), and/or c-FMS (the cellular receptor for colony stimulating factor-1 (CSF-1)). |
申请公布号 |
AU2014363894(A1) |
申请公布日期 |
2016.06.30 |
申请号 |
AU20140363894 |
申请日期 |
2014.12.10 |
申请人 |
GENZYME CORPORATION |
发明人 |
KANE JR., JOHN L.;MATTHEWS, GLORIA;METZ, MARKUS;KOTHE, MICHAEL;LIU, JINYU;SCHOLTE, ANDREW |
分类号 |
C07D413/14;A61K31/4184;A61K31/437;A61P35/00;C07D403/04;C07D403/14;C07D417/14;C07D487/04;C07D487/08;C07D487/10;C07F9/50 |
主分类号 |
C07D413/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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