| 发明名称 |
ASSAY FOR SCREENING COMPOUNDS THAT SELECTIVELY DECREASE THE NUMBER OF CANCER STEM CELLS |
| 摘要 |
The present invention provides, inter alia, a method for identifying an agent that selectively decreases the number of cancer stem cells (CSCs). This method includes (a) contacting a CSC from a population of cells with a candidate agent; and (b) determining whether the candidate agent reduces the survival or growth of the CSC or increases differentiation of the CSC relative to a CSC that has not been contacted with the candidate agent. The method may be used as a high throughput screen. |
| 申请公布号 |
US2016187320(A1) |
申请公布日期 |
2016.06.30 |
| 申请号 |
US201514808514 |
申请日期 |
2015.07.24 |
| 申请人 |
THE ROGOSIN INSTITUTE |
发明人 |
SMITH Barry;Cordon-Cardo Carlos;Petrylak Daniel;Domenech Josep;Martin Mireia Castilla |
| 分类号 |
G01N33/50;A61K38/05;A61K31/4355 |
主分类号 |
G01N33/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for identifying an agent that selectively decreases the number of cancer stem cells (CSCs) comprising:
a. contacting a CSC from a population of cells with a candidate agent; and b. determining whether the candidate agent reduces the survival or growth of the CSC or increases differentiation of the CSC relative to a CSC that has not been contacted with the candidate agent. |
| 地址 |
New York NY US |
