| 发明名称 |
ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| 摘要 |
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ANGPTL3 gene, as well as methods of inhibiting expression of ANGPTL3 and methods of treating subjects having a disorder of lipid metabolism, such as hyperlipidemia or hypertriglyceridemia, using such dsRNA compositions. |
| 申请公布号 |
US2016186180(A1) |
申请公布日期 |
2016.06.30 |
| 申请号 |
US201615068912 |
申请日期 |
2016.03.14 |
| 申请人 |
Alnylam Pharmaceuticals, Inc. |
发明人 |
Bettencourt Brian;Querbes William;Fitzgerald Kevin;Frank-Kamenetsky Maria;Milstein Stuart;Shulga Morskaya Svetlana |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of ANGPTL3, wherein said dsRNA comprises a sense strand and an antisense strand, wherein said sense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:1 and said antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:5. |
| 地址 |
Cambridge MA US |
