发明名称 PROCESS FOR PREPARING COORDINATIVE COMPOUNDS OF ND() COMPRISING AMPIROXICAM AND LORNOXICAM AS LIGANDS
摘要 The invention relates to a process for preparing coordinative compounds of Nd(III) comprising, as ligands, oxicams with antitumoral/anti-inflammatory activity. According to the invention, the process consists in bringing an alcoholic solution containing neutral/deprotonated oxicam into contact with an aqueous solution containing Nd(III) chloride/acetate in a molar ratio of 2 : 1, which leads, by refluxing, to the formation of the coordinative Nd(III) compounds, where the metallic ion shows a distorted octahedral stereochemistry, comprising water molecules in axial positions.
申请公布号 RO131196(A2) 申请公布日期 2016.06.30
申请号 RO20140000942 申请日期 2014.12.03
申请人 INSTITUTUL NAŢIONAL DE CERCETARE-DEZVOLTARE CHIMICO-FARMACEUTICĂ - ICCF BUCUREŞTI 发明人 NIŢĂ SULTANA;PATRON LUMINIŢA ILEANA;ANDRIEŞ ADRIAN;RĂDULESCU FLAVIAN;ALBULESCU RADU NICOLAE AUREL;FALCOŞ MARIANA;VINTILĂ MIHAELA
分类号 A61K31/5415;A61K47/02 主分类号 A61K31/5415
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