发明名称 |
COMPOSITION CONTAINING MONOACETYLDIACYLGLYCEROL COMPOUND AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASES |
摘要 |
The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-±, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases. |
申请公布号 |
EP3037093(A1) |
申请公布日期 |
2016.06.29 |
申请号 |
EP20140838604 |
申请日期 |
2014.08.19 |
申请人 |
ENZYCHEM LIFESCIENCES CORPORATION;KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY |
发明人 |
OH, SEI-RYANG;AHN, KYUNG SEOP;LEE, SU UI;SHIN, IN SIK;KWON, OK-KYOUNG;KIM, SEUNG HYUNG;CHUN, CHAN MI;LEE, TAE-SUK;HAN, YONG-HAE;SOHN, KI YOUNG;KANG, JONGKOO;KIM, HYE KYUNG |
分类号 |
A61K31/22;A61K31/20;A61P11/00 |
主分类号 |
A61K31/22 |
代理机构 |
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地址 |
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