| 发明名称 |
TGF-BETA RECEPTOR TYPE II VARIANTS AND USES THEREOF |
| 摘要 |
In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of T&bgr;RII polypeptide useful to selectively antagonize a T&bgr;RII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGF&bgr; associated disorders. |
| 申请公布号 |
EP3036262(A1) |
申请公布日期 |
2016.06.29 |
| 申请号 |
EP20140837885 |
申请日期 |
2014.08.21 |
| 申请人 |
ACCELERON PHARMA INC. |
发明人 |
KUMAR, RAVINDRA;GRINBERG, ASYA;SAKO, DIANNE, S.;CASTONGUAY, ROSELYNE;STEEVES, RITA |
| 分类号 |
C07K19/00;A61K38/17;A61P9/10;A61P35/00;C07K14/495;C07K14/71;C07K16/22 |
主分类号 |
C07K19/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
