PEGYLATED VEGF-TRAP AND METHOD FOR PREPARATION THEREOF

摘要

The present invention relates to a pegylated VEGF trap, and a preparation method thereof. More particularly, the present invention relates to a SEG-VEGF trap having enhanced half life and anti-cancer effect by performing pegylation after introducing a thiol group to C-terminal of a VEGF trap, and a preparation method thereof. The pegylated VEGF trap according to the present invention is well known as an anti-cancer medicine having increased half life in comparison to a conventional VEGF trap and enhanced anti-cancer effect through position-specific pegylation after substituting C-terminal with cysteine having a thiol group.