ANTISENSE MOLECULES FOR TREATMENT FOR TREATMENT OF STAPHYLOCOCCUS AUREUS INFECTION

摘要

Disclosed are antisense molecules and compositions for the treatment of Staphylococcus aureus infection. The antisense molecules and compositions comprise nucleic acid molecules, such as RNA, DNA, or nucleic acid molecules with modified backbones, such as PNA. The antisense molecules and compositions inhibit expression of membrane stability proteins in Staphyloccoccus aureus; are optionally conjugated to cell penetration molecules such as peptides; and are optionally administered in the form of a nanoparticle composition.

主权项

1. An antisense molecule or salt thereof that inhibits the growth of Staphylococcus aureus comprising a polynucleotide sequence that is antisense to the coding region of a Staphylococcus aureus membrane stability protein and hybridizes to said coding region under physiological conditions, wherein said antisense molecule is 10 to 50 nucleobases in length, with the proviso that said membrane protein is not FmhB.