发明名称 |
HIGH ASPECT RATIO NANOFIBRIL MATERIALS |
摘要 |
The present invention features linear and three-dimensional supramolecular materials self-assembled from block co-polymers comprising oligo(ethylene sulfide) (OES). The block copolymers assemble into fibrils, micelles, or matrices. The fibrillar materials are sensitive to oxidation, which leads to decreased OES block hydrophobicity and crystallinity, and increased water solubility of the polymer constituents. Molecular loading options, coupled with oxidative sensitivity, allow implantable or injectable fibrillar suspensions or cross-linked three-dimensional matrices to demonstrate significant biomedical potential, especially in the context of extracellular and intracellular molecular delivery and applications related to infection and disease. |
申请公布号 |
US2016177036(A1) |
申请公布日期 |
2016.06.23 |
申请号 |
US201414907370 |
申请日期 |
2014.07.24 |
申请人 |
The University of Chicago |
发明人 |
Hubbell Jeffrey A.;Brubaker Carrie E.;Velluto Diana |
分类号 |
C08G75/08;A61K47/34;A61K47/48;C08L81/02 |
主分类号 |
C08G75/08 |
代理机构 |
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代理人 |
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主权项 |
1. A block copolymer comprising a hydrophilic block and an oligo(ethylene sulfide) (OES) block. |
地址 |
Chicago IL US |