SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS

摘要

Disclosed are compounds of general formula A useful as potential anti-tubercular agents. The general formula A is;

主权项

1. A method of treating a mycobacterial infection, wherein said method comprises administering a to a patient a composition comprised of a benzothiazole compound of general formulae A wherein X═—N═CH—, —NH—CO—, —CO—, wherein Ar=Phenyl, 4-methylphenyl, 4-methoxyphenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-fluorophenyl, 4-chlorophenyl, 2-chloro-3-methoxyphenyl, 3,5-dimethoxyphenyl, 3,4,5-trimethoxyphenyl, pyridyl, nicotenyl, isonicotinyl, 5-nitro-2-furyl, styryl, 4-fluorostyryl, 4-methylstyryl, 4-methoxystyryl, 4-trifluorostyryl, 4-trifluoromethoxystyryl, 5-nitro-2-furyl, 1-methyl-4-nitro-1H-2-pyrrolyl, 1-methyl-5-nitro-1H-2-imadazolyl, 1-methyl-3-nitro-1H-2-pyrazolyl, and wherein R=Hydro, Methyl, Methoxy, Trifluoromethyl, Trifluoromethoxy, Fluoro, Chloro, Nitro, 5-Nitrofuran-2-carboxamide, 5-Nitrothiophene-2-carboxamide, 1-methyl-4-nitro-1H-2-pyrrolcarboxamide, 1-methyl-5-nitro-1H-2-imadazolcarboxamide, 1-methyl-3-nitro-1H-2-pyrazolcarboxamide.