ARYL HYDROCARBON RECEPTOR (AhR) MODIFIERS AS NOVEL CANCER THERAPEUTICS

摘要

Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.

主权项

1. A composition comprising wherein: X′ is alkyl, aryl or a substituted amino; n is 1; R2 is a substituted heteroaryl, R3, R4, R5 and R6 are H, and pharmaceutically acceptable salts thereof.