Compact Multimodality Optical Coherence Tomography Imaging Systems

摘要

Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element in common, and the respective paths differ from each other by at least one optical element. The OCT path and the image capture path share a common intermediate conjugate image plane. Focal control is achieved for the OCT path and the image capture path concurrently through adjustment of one or more common optical elements distal to the common intermediate conjugate plane, such that focal control requires no differential adjustment between optical elements not in common to both paths.

主权项

1. A system for imaging a subject, the system comprising:
two imaging paths, a scanning beam optical coherence tomography (OCT) imaging path and a video imaging path, wherein the scanning beam OCT imaging path comprises: a source of broadband optical radiation; a beamsplitter dividing the source of broadband optical radiation into a reference path and a sample path; and a beamsplitter that mixes source light reflected from the subject in the sample path with source light returned from a reference reflector in the reference path to create a wavelength dependent interferogram directed along a detection path to a detection module; wherein the video imaging path comprises: an illumination path including a source of optical radiation for illuminating the sample; an image capture path including an image capture device for capturing an image of an illuminated region of the subject; a beam combiner for coupling the illumination path with the image capture path; and a dichroic beamsplitter configured to couple the scanning beam OCT imaging path and the video imaging path, wherein the scanning beam OCT imaging path and the video imaging path share a common objective lens; wherein the illuminator is a fiber ring illuminator; wherein a ring of illumination for the fiber ring illuminator is coaxial with the scanning beam OCT imaging path over a region where the scanning beam OCT imaging path and the video imaging path are in common; and wherein the fiber ring illuminator comprises a ring of optical fibers that defines an annulus.