Provided in the application is a interleukin 15 (IL-15) protein complex. The IL-15 protein complex consists of a soluble fusion proteins (I) and (II), wherein the fusion protein (I) is a IL-15 polypeptide or a functionality fragment thereof, and the fusion protein (II) is a IL-15Rα polypeptide or a functionality fragment thereof. There are one or more amino acid sites on the fusion proteins (I) or (II) were mutated to Cys, which were paired with the corresponding Cys mutated from the amino acid sites on the fusion proteins (II) or(I) to form disulfide bonds. The IL-15 protein complex can be used for tumour therapy.
申请公布号
WO2016095642(A1)
申请公布日期
2016.06.23
申请号
WO2015CN94780
申请日期
2015.11.17
申请人
JIANGSU HENGRUI MEDICINE CO., LTD.;SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.