| 主权项 |
1. A compound of the formula (I) in which A is —NH—, —N(C1-C3-alkyl)- or —O—, X is —N— or —CH—, n is 0, 1 or 2, R1 is a —C(═O)NR7R8 or —S(═O)2NR7R8 group,
oris 5-membered monocyclic heteroaryl- which may optionally be mono-, di- or trisubstituted identically or differently by halogen, cyano, C1-C4-alkyl-, C2-C4-alkenyl-, C2-C4-alkynyl-, halo-C1-C4-alkyl-, C1-C4-alkoxy-, halo-C1-C4-alkoxy-, C1-C4-alkylthio-, halo-C1-C4-alkylthio-,—NR9R10, —C(═O)OR11, —C(═O)N9R10, —C(═O)R11, —S(═O)2R11, or —S(═O)2NR9R10, R2 is hydrogen, halogen, cyano, C1-C3-alkyl-, C2-C4-alkenyl-, C2-C4-alkynyl-, halo-C1-C4-alkyl-, C1-C4-alkoxy-, halo-C1-C4-alkoxy-, C1-C4-alkylthio- or halo-C1-C4-alkylthio-, and, if n is 2, R2 may be the same or different, or R1 and R2 together are a *—S(═O)2—NR8—CH2—**, *—S(═O)2—NR8—CH2—CH2—**, *—C(═O)—NR8—CH2—** or *—C(═O)—NR8—CH2—CH2—** group in which “*” denotes the attachment point of R1 to the phenyl ring in formula (I), and in which “**” denotes a carbon atom of this phenyl ring adjacent to this attachment point, R3 is methyl- or ethyl-, R4 is hydrogen or C1-C3-alkyl-, R5 is hydrogen or C1-C3-alkyl-,
or R4 and R5 together with the carbon atom to which they are bonded are C3-C6-cycloalkylene, R6 is C1-C6-alkyl- which may optionally be monosubstituted by C1-C3-alkoxy-, phenyl-, C3-C8-cycloalkyl-, or 4- to 8-membered heterocycloalkyl-,
in which phenyl- may itself optionally be mono-, di- or trisubstituted identically or differently by: halogen, cyano, C1-C4-alkyl-, C2-C4-alkenyl-, C2-C4-alkynyl-, C1-C4-alkoxy-, halo-C1-C4-alkyl-, or halo-C1-C4-alkoxy-, andin which C3-C8-cycloalkyl- and 4- to 8-membered heterocycloalkyl- may themselves optionally be mono- or disubstituted identically or differently by C1-C3-alkyl-,oris C3-C8-cycloalkyl- or 4- to 8-membered heterocycloalkyl-, which may optionally be mono- or disubstituted identically or differently by C1-C3-alkyl- or C1-C4-alkoxycarbonyl-,oris phenyl which may optionally be mono- or disubstituted identically or differently by halogen, C1-C3-alkyl- or 4-8-membered heterocycloalkyl-,in which the 4-8-membered heterocycloalkyl- may itself optionally be mono- or disubstituted identically or differently by C1-C3-alkyl or C1-C4-alkoxycarbonyl-, R7 is hydrogen,
oris C1-C6-alkyl- which may optionally be mono-, di- or trisubstituted identically or differently by: hydroxyl, oxo, fluorine, cyano, C1-C4-alkoxy-, halo-C1-C4-alkoxy-, —NR9R10, C3-C8-cycloalkyl-, C4-C8-cycloalkenyl-, 4- to 8-membered heterocycloalkyl-, 4-bis 8-membered heterocycloalkenyl-, C5-C11-spirocycloalkyl-, C5-C11-heterospirocycloalkyl-, bridged C6-C12-cycloalkyl-, bridged C6-C12-heterocycloalkyl-, C6-C12-bicycloalkyl-, C6-C12-heterobicycloalkyl-, phenyl-, or 5- to 6-membered heteroaryl-,in which C3-C8-cycloalkyl-, C4-C8-cycloalkenyl-, 4- to 8-membered heterocycloalkyl-, 4- to 8-membered heterocycloalkenyl-, C5-C11-spirocycloalkyl-, C5-C11-heterospirocycloalkyl-, bridged C6-C12-cycloalkyl-, bridged C6-C12-heterocycloalkyl-, C6-C12-bicycloalkyl-, and C6-C12-heterobicycloalkyl- may itself optionally be mono- or disubstituted identically or differently by: hydroxyl, fluorine, oxo, cyano, C1-C3-alkyl-, fluoro-C1-C3-alkyl-, C3-C6-cycloalkyl-, cyclopropylmethyl-, C1-C3-alkylcarbonyl-, C1-C4-alkoxycarbonyl- or —NR9R10, andin which phenyl and 5- to 6-membered heteroaryl may optionally be mono- or disubstituted identically or differently by: halogen, cyano, trifluoromethyl-, C1-C3-alkyl-, or C1-C3-alkoxy-,oris C3-C6-alkenyl- or C3-C6-alkynyl-,oris C3-C8-cycloalkyl-, C4-C8-cycloalkenyl-, C5-C1i-spirocycloalkyl-, bridged C6-C12-cycloalkyl- or C6-C12-bicycloalkyl-, which may optionally be mono- or disubstituted identically or differently by: hydroxyl, oxo, cyano, fluorine, C1-C3-alkyl, C1-C3-alkoxy, trifluoromethyl, or —NR9R10,oris 4- to 8-membered heterocycloalkyl-, 4- to 8-membered heterocycloalkenyl-, C5-C11-heterospirocycloalkyl-, bridged C6-C12-heterocycloalkyl- or C6-C12-heterobicycloalkyl-, which may optionally be mono- or disubstituted identically or differently by: hydroxyl, fluorine, oxo, cyano, C1-C3-alkyl-, fluoro-C1-C3-alkyl-, C3-C6-cycloalkyl-, cyclopropylmethyl-, C1-C3-alkylcarbonyl-, C1-C4-alkoxycarbonyl- or —NR9R10, R8 is hydrogen or optionally singly or doubly, identically or differently hydroxyl-, oxo- or C1-C3-alkoxy-substituted C1-C3-alkyl-, or fluoro-C1-C3-alkyl,
or R7 and R8 together with the nitrogen atom to which they are bonded are 4- to 8-membered heterocycloalkyl, 4- to 8-membered heterocycloalkenyl-, C5-C1-heterospirocycloalkyl-, bridged C6-C12-heterocycloalkyl- or C6-C12-heterobicycloalkyl-, which may optionally be mono- or disubstituted identically or differently by: hydroxyl, fluorine, oxo, cyano, C1-C3-alkyl-, fluoro-C1-C3-alkyl-, C3-C6-cycloalkyl-, cyclopropylmethyl-, C1-C3-alkylcarbonyl-, C1-C4-alkoxycarbonyl- or —NR9R10, R9 and R10 are each independently hydrogen or optionally singly or doubly, identically or differently hydroxyl-, oxo- or C1-C3-alkoxy-substituted C1-C3-alkyl, or fluoro-C1-C3-alkyl, or 4- to 8-membered heterocycloalkyl,
in which the 4- to 8-membered heterocycloalkyl- may itself optionally be mono- or disubstituted identically or differently by C1-C3-alkyl,or R9 and R10 together with the nitrogen atom to which they are attached are 4- to 8-membered heterocycloalkyl- which may optionally be mono- or disubstituted identically or differently by: hydroxyl, fluorine, oxo, cyano, C1-C3-alkyl-, fluoro-C1-C3-alkyl-, C3-C6-cycloalkyl-, cyclopropylmethyl-, C1-C3-alkylcarbonyl- or C1-C4-alkoxycarbonyl-, R11 is C1-C6-alkyl or phenyl-C1-C3-alkyl, or a diastereomer, racemate, polymorph or physiologically acceptable salt thereof. |
