| 发明名称 |
STEM CELLS FOR MODELING TYPE 2 DIABETES |
| 摘要 |
The invention provides stem cell derived beta-pancreatic cells and animal models of T2D in which cells have been grafted. The stem cells bear a mutated form of SLC30A8 conferring protection or susceptibility to T2D. The cells and animal models can be used for drug screening as well as to provide insights into the mechanism of T2D and potentially new therapeutic and diagnostic targets. |
| 申请公布号 |
WO2016100857(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
WO2015US66757 |
申请日期 |
2015.12.18 |
| 申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
GONG, GUOCHUN;LAI, KA-MAN VENUS;VALENZUELA, DAVID M. |
| 分类号 |
C12N5/074;A61K35/12;A61K35/39;A61K35/545;C12N5/071;C12N15/10;C12N15/113;C12N15/63;C12N15/90 |
主分类号 |
C12N5/074 |
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