| 发明名称 |
COUPLING METHOD FOR PEPTIDE SYNTHESIS AT ELEVATED TEMPERATURES |
| 摘要 |
An improved method for coupling carboxylic acids and amines is disclosed that includes the steps of combining a hyper-acid sensitive linker connecting an amine and a resin, a carboxylic acid, a carbodiimide, an activator additive, and a base, and carrying out the activation and coupling at a temperature greater than 30° C. |
| 申请公布号 |
US2016176918(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
US201514969004 |
申请日期 |
2015.12.15 |
| 申请人 |
CEM CORPORATION |
发明人 |
COLLINS JONATHAN M.;SINGH SANDEEP KUMAR |
| 分类号 |
C07K1/10;C07K7/08;C07K7/06;C07K14/575;C07K14/00 |
主分类号 |
C07K1/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. In a method for coupling carboxylic acids and amines, the improvement comprising:
combining a hyper-acid sensitive linker connecting an amine and a resin, a carboxylic acid, a carbodiimide, an activator additive, and a base; and carrying out the activation and coupling at a temperature greater than 30° C. |
| 地址 |
MATTHEWS NC US |
