发明名称 |
PURIFICATION OF TAXANES |
摘要 |
Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water. |
申请公布号 |
US2016176837(A1) |
申请公布日期 |
2016.06.23 |
申请号 |
US201615053793 |
申请日期 |
2016.02.25 |
申请人 |
Phyton Holdings, LLC |
发明人 |
Bucher Brian A.;Desimone, III Edward M.;Franke Roland R.;Gallagher Rex T.;Hand Barry J.;Howe Christopher D.;Johnson James H.;Juchum John S.;Plante Marc A.;Sambandam T.G.;Yang Dong S. |
分类号 |
C07D305/14 |
主分类号 |
C07D305/14 |
代理机构 |
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代理人 |
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主权项 |
1. A method of crystallizing docetaxel comprising:
(a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride; and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water. |
地址 |
San Antonio TX US |