ANTIGEN DELIVERY SYSTEM

摘要

The disclosure provides a minimal antigen delivery system consists essentially of PEGylated stealth liposomes loaded with an immunogenic human leukocyte antigen (HLA) class restricted peptide and surface modified with a cell targeting peptide which mediates binding and internalization of the liposomes into a target cell. Further disclosed are a HLA class 1 restricted peptide that is measles virus hemagglutinin peptide H250, and a cell-targeting peptide that is H 1299.3 for targeting cancer cells.