主权项 |
1. The compound of the formulawherein:
R isor a heterocylic or heterobicyclic group substituted with 0-4 R2;
X1, X2, X3 and X4 are independently —CR4 or —N—, wherein at least one is —N—; R1 is hydrogen, (C1-C6)alkyl, (C3-C8)cycloalkyl, —CONHR9, —COOR9, —COR9 or —SO2R9, any of which except the hydrogen is substituted with 0-3 Rx; Rx is hydrogen, halogen, —OH, halo(C1-C3)alkyl, hydroxy(C1-C3)alkyl, -amino(C1-C3)alkyl, or —CN; R2 is independently one or more hydrogen, —CD3, OCD3, halogen, —CF3, —CHF2, —CN, (C1-C6)alkyl, (C1-C6)alkoxy or —SO2 (C1-C6)alkyl; R3 is independently one or more hydrogen, CD3, OCD3, halogen, —CN, (C1-C6)alkyl, (C2-C6)alkenyl, (C1-C6)alkoxy, (C3-C8)cycloalkyl, hydroxy(C1-C3)alkyl, (C1-C6)alkylamino-, (C1-C6)alkylamino(C1-C6)alkyl, 5-6 membered heteroaryl, heterocyclyl, O-heterocyclyl, —NR5R6, —CONR5R6, —COOR4, —COR4, —SO2R4, —CHCF2COOCH2OH or —CHCF2CONH2, any of which except the hydrogen is substituted with 0-4 Ry; Ry is hydrogen, halogen, —OH, (C1-C3)alkyl, halo(C1-C3)alkyl, hydroxy(C1-C3)alkyl, -amino(C1-C3)alkyl, —NHCOOH, or —CN; R4 is hydrogen or (C1-C6)alkyl; R5 and R6 are independently hydrogen, —C(O)alkyl or (C1-C6)alkyl; or R5 and R6 can be taken together with the nitrogen atom to which they are attached to form a 5-7 membered heterocyclo ring; R7 is independently one or more hydrogen, halogen, halo(C1-C6)alkyl or —CN; R8 is hydrogen, (C1-C6)alkyl, (C3-C8)cycloalkyl, —CONHR9, —COOR9, —COR9 or —SO2R9; R9 is hydrogen, (C1-C6)alkyl, (C3-C8)cycloalkyl, heterocyclylalkyl-, heterocyclyl(C1-C3)alkylamino(C1-C3)alkyl- or (C1-C3)alkylamino(C1-C3)alkyl; m is 0, 1, 2, 3, or 4; n is 0, 1, 2 or 3; and/or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof. |