| 主权项 |
1. A compound of Formula (I): wherein R5 is H or methyl; R9 is —H, methyl, or hydroxyl; R10 is —H, methyl, hydroxyl, or NR11R12, and wherein R11 and R12 are independently selected, and wherein R11 is —H, methyl, or —CH2—C(O)CH2CH3; and R12 is
—H, oxopyrrolidinyl, dioxidothiopyranyl, isopropylsulfonyl, tetrahydropyranyl, oxetanyl, tetrahydrofuranyl, hydroxyl, dimethylaminethanesulfonyl, aminethanesulfonyl, dimethylaminpropanesulfonyl,C1-C6 alkyl that is linear, branched, or cyclic, optionally substituted with methoxy, —F, ≡N, methyl oxetanyl, ethoxy, oxo-, methyl imidazolyl, methylthio piperazinyl optionally substituted with methyl or —CF3,
acetamidyl optionally substituted with methyl or ethyl,oxazolyl optionally substituted with methyl,pyrazolyl optionally substituted with methyl, cyano, or hydroxyl,—C(O)R13, wherein R13 is
C1 to C7 alkyl that is cyclic, branched, or linear, optionally substituted with NR13R14, wherein R13 and R14 are independently selected from methyl and —H;
methoxy, hydroxyl, methylthio, ethylthio, methylsulfonyl, oxo-, thiazolidinyl, pyridinyl, pyrazolopyridinyl, methyl amino, thiazolyl, —F, morpholinyl, methylisoxazolyl, methyl oxetanyl, aminooxetanyl,phenyl optionally substituted with hydroxyl, —C(O)NH2;a five membered cycloalkyl, saturated or unsaturated, in which 1 or 2 carbon atoms are replaced by nitrogen atoms, wherein the cycloamine or cyclodiamine is optionally substituted with hydroxyl or methyl. |
