SYNERGISTIC CO-ADMINISTRATION OF COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA
摘要
The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.
申请公布号
WO2016100922(A1)
申请公布日期
2016.06.23
申请号
WO2015US66882
申请日期
2015.12.18
申请人
OREGON HEALTH & SCIENCE UNIVERSITY;SANOFI PASTEUR, INC.
发明人
ROSS, TED, MILBURN;ALEFANTIS, TIM;CARTER, DONALD, MARTIN, JR.;DARBY, CHRISTOPHER, AUSTIN;KLEANTHOUS, HAROLD