| 摘要 |
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/052965 A2 11 April 2013 (11.04.2013) W I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 48/00 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/US2012/059349 DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 9 October 2012 (09.10.2012) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (26) Publication Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (30) Priority Data: ZM, ZW. 61/544,187 6 October 2011 (06.10.2011) US 61/638,345 25 April 2012 (25.04.2012) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicants: MIRAGEN THERAPEUTICS [US/US]; GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, 6200 Lookout Road, Boulder, Colorado 80301 (US). THE UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, BOARD OF REGENTS, THE UNIVERSITY OF TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, TEXAS SYSTEM [US/US]; 201 West 7th Street, Austin, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Texas 78701 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (72) Inventors: ROOIJ, Eva van; c/o MIRAGEN THERA- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, PEUTICS, 6200 Lookout Road, Boulder, Colorado 80301 ML, MR, NE, SN, TD, TG). (US). OLSON, Eric; 3219 Southwestern Blvd., Dallas, Published: Texas 75225 (US). GRUETER, Chad; 520 Winchester _ without international search report and to be republished Dr., Richardson, Texas 75080 (US). upon receipt of that report (Rule 48.2(g)) i (74) Agents: MCLEOD, Bonnie Weiss et al.; Cooley LLP, 777 6th Street, N.W., Suite 1100, Washington, District of Columbia 20001 (US). (54) Title: CONTROL OF WHOLE BODY ENERGY HOMEOSTASIS BY MICRORNA REGULATION A Vo~~l rUG;RE 4A-1- A e A 30 20- Anti208a HF -Ant20a Weeks Weeks (57) Abstract: The present invention provides a method of regulating fatty acid or glucose metabolism in a cell by contacting the cell with a modulator of miR-208a and/or miR-208b activity or expression. The present invention also provides a method of treating f4 or preventing a metabolic disorder, such as obesity, diabetes, or metabolic syndrome, in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression. Also provided is a method of enhancing or improving mitochondrial function and/or redox-homeostasis in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression. |
