发明名称 |
COMPOSITIONS AND METHODS FOR DELIVERING MESSENGER RNA |
摘要 |
The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The lipid particles comprise a cationic lipid, a non-cationic lipid, and an mRNA molecule that is encapsulated within the lipid particle. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provides cationic lipids that are useful for preparing the compositions of the invention. |
申请公布号 |
EP3033325(A1) |
申请公布日期 |
2016.06.22 |
申请号 |
EP20140829948 |
申请日期 |
2014.07.22 |
申请人 |
PROTIVA BIOTHERAPEUTICS, INC. |
发明人 |
HEYES, JAMES;PALMER, LORNE R.;REID, STEPHEN P.;YAWORSKI, EDWARD D.;MACLACHLAN, IAN;WOOD, MARK;MARTIN, ALAN D. |
分类号 |
C07C229/12;A61K9/50;A61K47/18;A61K47/24;A61K47/28;A61K48/00;C07H21/02;C12N15/11;C12N15/88 |
主分类号 |
C07C229/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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