APTAMER-BASED BIOSENSING

摘要

The present invention relates to a biosensor device (10) for detecting a predetermined target analyte. The device comprises a substrate (13). An aptamer bioreceptor (21) for specifically binding to the predetermined target analyte is exposed at a functionalized surface of the substrate. The device also comprises a heat source (11) for heating the substrate (13) via a back surface thereof. The device further comprises a first temperature sensing element (14) for sensing a temperature at the back side of the substrate (13) and a second temperature sensing element (15) for sensing a temperature at the functionalized side of the substrate (13). The device also comprises a signal processing unit (16) for calculating a heat transfer resistivity value based on temperature values obtained from the first and the second temperature sensing element and the heating power generated by the heat source (11).