发明名称 可溶性RNAキャップ結合ポケット断片、及びその使用
摘要 The present invention relates to soluble fragments of the Influenza virus RNA dependent RNA polymerase subunit PB2 and variants thereof, and crystallized complexes thereof comprising an RNA cap analog. This invention also relates to computational methods using the structural coordinates of said complex to screen for and design compounds that interact with the RNA cap binding pocket. In addition, this invention relates to methods identifying compounds that bind to PB2 polypeptide fragments comprising the RNA cap binding pocket, preferably inhibit the interaction with RNA caps or analogs thereof, by using said PB2 polypeptide fragments, preferably in a high-throughput setting. This invention also relates to compounds and pharmaceutical compositions comprising the identified compounds for the treatment of disease conditions due to viral infections caused by negative-sense single stranded RNA viruses.
申请公布号 JP5937169(B2) 申请公布日期 2016.06.22
申请号 JP20140207447 申请日期 2014.10.08
申请人 ヨーロピアン モレキュラー バイオロジー ラボラトリー 发明人 キューザック,ステファン;グイリガイ,ディルフィーヌ;ハート,ダレン;タレンデュー,フランク
分类号 C12N15/09;C07K14/11;G01N33/50 主分类号 C12N15/09
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