DIAGNOSIS OF CANCER BY MEANS OF METHYLATION MARKER

摘要

A method of screening for the onset or predisposition to the onset of a large intestine neoplasm or monitoring the progress of a neoplasm in an individual, said method comprising assessing the methylation status of a DNA region selected from: the region defined by Hg19 coordinates chr7:50344378..50472799 and 2kb upstream of the transcription start site; or the gene region, including 2kb upstream, of IKZF1 in a biological sample from said individual wherein a higher level of methylation of the DNA regions of group (i) and/or (ii) relative to control levels is indicative of a large intestine neoplasm or a predisposition to the onset of a large intestine neoplastic state.