发明名称 |
METHODS OF TREATMENT OF HPV RELATED DISEASES |
摘要 |
The present invention provides methods of mucosal tissue administration of therapeutic HPV vaccines, in a prime-boost regimen, which generated antigen-specific CD8+ T cell-mediated immune responses and the expression of tissue-resident memory T cell (Trm) markers on the CD8+ T cells. In some embodiments, the inventive methods employed pNGVL4a-sig/E7(detox)/HSP70 DNA vaccine and TA-HPV in a prime-boost regimen which shows vaccination in the infected mucosal tissues, including those in the cervicovaginal tract, elicited potent antitumor effects and a more effective local immune response in the tissues and regional lymph node, when compared to intramuscular vaccination. Furthermore, targeting the induction of Trm-mediated immune responses can serve as an ideal methodology especially for therapeutic HPV vaccines. |
申请公布号 |
EP3030261(A1) |
申请公布日期 |
2016.06.15 |
申请号 |
EP20140834669 |
申请日期 |
2014.08.06 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
WU, TZYY-CHOOU;HUNG, CHIEN-FU;RODEN, RICHARD |
分类号 |
A61K39/12;A61P31/20;A61P35/00 |
主分类号 |
A61K39/12 |
代理机构 |
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