发明名称 |
NOVEL ANTI-HUMAN TSLP RECEPTOR ANTIBODY |
摘要 |
[Problem] To provide an anti-human TSLP receptor antibody that specifically binds to human TSLP receptor and inhibits an action of human TSLP through human TSLP receptor. [Means for Solution] An anti-human TSLP receptor antibody had been studied by the present inventors, and an anti-human TSLP receptor antibody comprising a heavy chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 118 of SEQ ID NO: 1 and a light chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 108 of SEQ ID NO: 3 was provided. It was revealed that the anti-human TSLP receptor antibody inhibits expression of TARC mRNA induced by TSLP and production of MDC proteins, and suppressed an allergic reaction in a monkey Ascaris antigen sensitization model, and then the present invention was completed. |
申请公布号 |
EP3031913(A1) |
申请公布日期 |
2016.06.15 |
申请号 |
EP20140833804 |
申请日期 |
2014.08.08 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
SATO, HIROMU;YAMAJUKU, DAISUKE;ARAI, KAZUNORI;OGINO, MAKO |
分类号 |
C12N15/00;A61K39/395;A61P11/06;C07K16/28;C07K16/46;C12N5/10;C12N15/09;C12P21/08 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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