IMMUNOTHERAPEUTIC COMBINATIONS FOR THE TREATMENT OF TUMORS THAT OVER-EXPRESS GANGLIOSIDES
摘要
THE PRESENT INVENTION IS RELATED TO HUMAN MEDICINE AND MORE SPECIFICALLY TO CANCER IMMUNOTHERAPY. THIS INVENTION ALSO RELATES TO PROTECTIVE AND THERAPEUTIC VACCINES THAT INDUCE AN IMMUNE RESPONSE TO TUMORS THAT EXPRESS GANGLIOSIDES AND METHODS TO REDUCE TUMOR BURDEN. @THE METHODS DESCRIBED IN THE PRESENT INVENTION ARE BASED ON THE SYNERGIC THERAPEUTIC EFFECT OBTAINED BY COMBINATION OF IDIOTYPIC VACCINES. IDIOTYPIC VACCINES OF THE PRESENT INVENTION COMPRISES MURINE ANTI-GANGLIOSIDE ANTIBODIES (Ab1), SPECIFIC MURINE ANTI-IDIOTYPE ANTIBODIES AGAINST THE ANTI-GANGLIOSIDE (Ab2) AND GANGLIOSIDE VACCINES. @THE PRESENT INVENTION ALSO RELATES TO METHODS EFFECTIVE IN SUBJECTS TO REDUCE THE BURDEN OF TUMORS THAT EXPRESS GANGLIOSIDES.
申请公布号
MY157372(A)
申请公布日期
2016.06.15
申请号
MY2002PI01239
申请日期
2002.04.05
申请人
CENTRO DE INMUNOLOGIA MOLECULAR
发明人
FERNANDEZ MOLINA, LUIS ENRIQUE;VAZQUEZ LOPEZ, ANA MARIA;PEREZ RODRIGUEZ, ROLANDO;PEREZ GONZALEZ, ALEXIS;CARR PEREZ, ADRIANA;DIAZ RODRIGUEZ, YILDIAN;ALFONSO FERNANDEZ, MAURO A.;ADRIANA MARIA ROJAS DEL CALVO
